Gingivitis Research Today is a free monthly online journal that collates and summarizes the latest research about Gingivitis, including details on gum inflammation, plaque, treatment, oral hygiene.

Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease.

Skaleric U, Gaspirc B, McCartney-Francis N, Masera A, Wahl SM

Department of Oral Medicine & Periodontology, Faculty of Medicine, Hrvatski trg 6, 1000 Ljubljana, Slovenia. uros.skaleric@mf.uni-lj.si

Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.

Published 22 November 2006 in Infect Immun, 74(12): 7010-3.
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